1uea

X-ray diffraction
2.8Å resolution

MMP-3/TIMP-1 COMPLEX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Stromelysin-1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 173 amino acids
Theoretical weight: 19.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08254 (Residues: 100-272; Coverage: 38%)
Gene names: MMP3, STMY1
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)
Metalloproteinase inhibitor 1 Chains: B, D
Molecule details ›
Chains: B, D
Length: 184 amino acids
Theoretical weight: 20.65 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01033 (Residues: 24-207; Coverage: 100%)
Gene names: CLGI, TIMP, TIMP1
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P43
Unit cell:
a: 80.62Å b: 80.62Å c: 157.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 not available
Expression systems:
  • Escherichia coli
  • Cricetulus griseus