1u38

Solution NMR

Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Amyloid-beta A4 precursor protein-binding family A member 1 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02410 (Residues: 655-741; Coverage: 10%)
Gene names: APBA1, MINT1, X11
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
PVYI Chain: B
Molecule details ›
Chain: B
Length: 4 amino acids
Theoretical weight: 491 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided