X-ray diffraction
2.5Å resolution

Crystal structure of Mycobacterium tuberculosis Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) at 2.5A resolution with glycerol in the active site


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Probable low molecular weight protein-tyrosine-phosphatase Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 17.92 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
  • Canonical: P9WIA1 (Residues: 1-163; Coverage: 100%)
Gene names: MTCY427.15, Rv2234, ptpA
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 49.311Å b: 53.003Å c: 64.153Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.212 0.273
Expression system: Escherichia coli