1u2q

X-ray diffraction
2.5Å resolution

Crystal structure of Mycobacterium tuberculosis Low Molecular Weight Protein Tyrosine Phosphatase (MPtpA) at 2.5A resolution with glycerol in the active site

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable low molecular weight protein-tyrosine-phosphatase Chain: A
Molecule details ›
Chain: A
Length: 163 amino acids
Theoretical weight: 17.92 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WIA1 (Residues: 1-163; Coverage: 100%)
Gene names: MTCY427.15, Rv2234, ptpA
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 49.311Å b: 53.003Å c: 64.153Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.212 0.273
Expression system: Escherichia coli