› 1tt6

X-ray diffraction
1.8Å resolution

The orthorhombic crystal structure of transthyretin in complex with diethylstilbestrol

Released:
DOI: 10.2210/pdb1tt6/pdb
PDB entry 1tt6 coloured by chain, front view.
PDB entry 1tt6 coloured by chain, side view.
PDB entry 1tt6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.
Morais-de-Sá E, Pereira PJ, Saraiva MJ, Damas AM
J Biol Chem 279 53483-90 (2004)
PMID: 15469931

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand DES 2 x DES
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P21212
Unit cell:
a: 42.306Å b: 85.375Å c: 63.429Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.218
Expression system: Escherichia coli BL21

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Citations

5 review citations

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
Connelly et al. (2010)
4 more