Solution NMR

Solution structure of the Wiskott-Aldrich Syndrome Protein (WASP) autoinhibited core domain complexed with (S)-wiskostatin, a small molecule inhibitor


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Wiskott-Aldrich syndrome protein Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 11.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P42768 (Residues: 242-310; Coverage: 14%)
Gene names: IMD2, WAS
Structure domains: CRIB domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing; torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)