1t83

X-ray diffraction
3Å resolution

CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC)

Released:
Source organism: Homo sapiens
Primary publication:
The structure of a human type III Fcgamma receptor in complex with Fc.
J. Biol. Chem. 276 16469-77 (2001)
PMID: 11297532

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 224 amino acids
Theoretical weight: 25.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 107-330; Coverage: 68%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Low affinity immunoglobulin gamma Fc region receptor III-B Chain: C
Molecule details ›
Chain: C
Length: 176 amino acids
Theoretical weight: 20.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75015 (Residues: 19-194; Coverage: 81%)
Gene names: CD16B, FCG3, FCGR3, FCGR3B, IGFR3
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 73.846Å b: 102.385Å c: 123.069Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.226 0.282
Expression system: Escherichia coli BL21(DE3)