› 1slc

X-ray diffraction
2.15Å resolution

X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES

Released:
DOI: 10.2210/pdb1slc/pdb
PDB entry 1slc coloured by chain, front view.
PDB entry 1slc coloured by chain, side view.
PDB entry 1slc coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.
Bourne Y, Bolgiano B, Liao DI, Strecker G, Cantau P, Herzberg O, Feizi T, Cambillau C
Nat Struct Biol 1 863-70 (1994)
PMID: 7773775

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Galectin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 134 amino acids
Theoretical weight: 14.63 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P11116 (Residues: 2-135; Coverage: 99%)
Gene name: LGALS1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, NDG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P31
Unit cell:
a: 77.8Å b: 77.8Å c: 85.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 not available
Expression system: Not provided

Quick links

Citations

27 review citations

Animal lectins.
Gabius HJ. (1997)
26 more

3 mentions without citation

The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site.
Dormitzer et al. (2002)
2 more