PDBe 1shc

Solution NMR

SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SHC-transforming protein 1 Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 21.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29353 (Residues: 125-317; Coverage: 33%)
  • Best match: P29353-3 (Residues: 1-162)
Gene names: SHC, SHC1, SHCA
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
High affinity nerve growth factor receptor Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.51 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04629 (Residues: 489-500; Coverage: 2%)
Gene names: MTC, NTRK1, TRK, TRKA

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Escherichia coli
  • Not provided