› 1ruv

X-ray diffraction
1.25Å resolution

RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)

Released:
DOI: 10.2210/pdb1ruv/pdb
PDB entry 1ruv coloured by chain, front view.
PDB entry 1ruv coloured by chain, side view.
PDB entry 1ruv coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution.
Ladner JE, Wladkowski BD, Svensson LA, Sjölin L, Gilliland GL
Acta Crystallogr D Biol Crystallogr 53 290-301 (1997)
PMID: 15299932

Function and Biology Details

Reaction catalysed: 
(1a) an (RNA) containing cytidine = an (RNA)-3'-cytidine-2',3'-cyclophosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158390 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonuclease pancreatic Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P61823 (Residues: 27-150; Coverage: 100%)
Gene names: RNASE1, RNS1
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

2 bound ligands:
Ligand UVC 1 x UVC
Ligand TBU 1 x TBU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 29.8Å b: 38.2Å c: 53.2Å
α: 90° β: 106.1° γ: 90°
R-values:
R R work R free
0.197 0.197 not available

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Citations

5 review citations

Selective speciation improves efficacy and lowers toxicity of platinum anticancer and vanadium antidiabetic drugs.
Doucette et al. (2016)
4 more

11 mentions without citation

Hypervalent nonbonded interactions of a divalent sulfur atom. Implications in protein architecture and the functions.
Iwaoka et al. (2012)
10 more