› 1rsy

X-ray diffraction
1.9Å resolution

STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD

Released:
DOI: 10.2210/pdb1rsy/pdb
PDB entry 1rsy coloured by chain, front view.
PDB entry 1rsy coloured by chain, side view.
PDB entry 1rsy coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.
Sutton RB, Davletov BA, Berghuis AM, Südhof TC, Sprang SR
Cell 80 929-38 (1995)
PMID: 7697723

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.1 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P21707 (Residues: 127-266; Coverage: 33%)
Gene name: Syt1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 42.3Å b: 38.9Å c: 44.6Å
α: 90° β: 96.9° γ: 90°
R-values:
R R work R free
0.186 0.186 0.249
Expression system: Escherichia coli

Quick links

Citations

108 review citations

Membrane fusion: grappling with SNARE and SM proteins.
Südhof et al. (2009)
107 more

28 mentions without citation

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Shin et al. (2010)
27 more