› 1r9k

Solution NMR

Representative solution structure of the catalytic domain of SopE2

Released:
DOI: 10.2210/pdb1r9k/pdb
PDB entry 1r9k coloured by chain, front view.
PDB entry 1r9k coloured by chain, side view.
PDB entry 1r9k coloured by chain, top view.
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Primary publication:
solution structure, backbone dynamics, and interaction with Cdc42 of Salmonella guanine nucleotide exchange factor SopE2.
Williams C, Galyov EE, Bagby S
Biochemistry 43 11998-2008 (2004)
PMID: 15379540

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanine nucleotide exchange factor sopE2 Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 18.59 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7CQD4 (Residues: 69-240; Coverage: 72%)
Gene names: STM1855, sopE2
Sequence domains: SopE GEF domain
Structure domains: SopE-like, GEF domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

8 review citations

Salmonella type III secretion effectors: pulling the host cell's strings.
Schlumberger et al. (2006)
7 more

3 mentions without citation

Mimicking GEFs: a common theme for bacterial pathogens.
Orchard et al. (2012)
2 more