1r8u

Solution NMR

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cbp/p300-interacting transactivator 2 Chain: A
Molecule details ›
Chain: A
Length: 50 amino acids
Theoretical weight: 5.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99967 (Residues: 220-269; Coverage: 19%)
Gene names: CITED2, MRG1
Histone lysine acetyltransferase CREBBP Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45481 (Residues: 340-439; Coverage: 4%)
Gene names: Cbp, Crebbp
Sequence domains: TAZ zinc finger
Structure domains: TAZ domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: AMBER simulated annealing and minimization
Expression system: Escherichia coli BL21(DE3)