1qsc

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF2 IN A COMPLEX WITH A PEPTIDE FROM THE CD40 RECEPTOR

Released:
Source organism: Homo sapiens
Primary publication:
Crystallographic analysis of CD40 recognition and signaling by human TRAF2.
Proc. Natl. Acad. Sci. U.S.A. 96 8408-13 (1999)
PMID: 10411888

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
Non-polymer only hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TNF receptor-associated factor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 191 amino acids
Theoretical weight: 21.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q12933 (Residues: 311-501; Coverage: 38%)
Gene names: TRAF2, TRAP3
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
CD40 RECEPTOR Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 7 amino acids
Theoretical weight: 776 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2, SSRL BEAMLINE BL1-5
Spacegroup: P212121
Unit cell:
a: 87.11Å b: 90.09Å c: 92.63Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.257
Expression systems:
  • Spodoptera frugiperda
  • Not provided