X-ray diffraction
2.6Å resolution

Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Homoserine dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 38.54 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
  • Canonical: P31116 (Residues: 1-359; Coverage: 100%)
Gene names: HOM6, J2132, YJR139C
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand NHO 1 x NHO
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P43212
Unit cell:
a: 80.863Å b: 80.863Å c: 248.986Å
α: 90° β: 90° γ: 90°
R R work R free
0.247 0.247 0.306
Expression system: Escherichia coli