1q3p

X-ray diffraction
2.25Å resolution

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assemblies composition:
hetero tetramer (preferred)
hetero octamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SH3 and multiple ankyrin repeat domains protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.07 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WV48 (Residues: 654-762; Coverage: 5%)
Gene name: Shank1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
C-terminal hexapeptide from Guanylate kinase-associated protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 amino acids
Theoretical weight: 718 Da
Source organism: Rattus norvegicus
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P41212
Unit cell:
a: 60.763Å b: 60.763Å c: 157.902Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.251 0.28
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided