› 1q03

X-ray diffraction
2.05Å resolution

Crystal structure of FGF-1, S50G/V51G mutant

Released:
DOI: 10.2210/pdb1q03/pdb
PDB entry 1q03 coloured by chain, front view.
PDB entry 1q03 coloured by chain, side view.
PDB entry 1q03 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor.
Kim J, Lee J, Brych SR, Logan TM, Blaber M
Protein Sci 14 351-9 (2005)
PMID: 15632285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 146 amino acids
Theoretical weight: 16.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 74.9Å b: 97Å c: 108Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.227
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Model systems for beta-hairpins and beta-sheets.
Hughes et al. (2006)
4 other articles

1 mention without citation

Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor.
Kim et al. (2005)