PDBe 1psi

X-ray diffraction
2.92Å resolution

Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU

Released:
Source organism: Homo sapiens
Primary publication:
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Nat. Struct. Biol. 3 676-81 (1996)
PMID: 8756325

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 26-418; Coverage: 100%)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-11
Spacegroup: C2
Unit cell:
a: 112.958Å b: 38.508Å c: 88.928Å
α: 90° β: 104.85° γ: 90°
R-values:
R R work R free
0.218 0.218 0.288
Expression system: Escherichia coli