› 1pqr

Solution NMR

Solution Conformation of alphaA-Conotoxin EIVA

Released:
DOI: 10.2210/pdb1pqr/pdb
PDB entry 1pqr coloured by chain, ensemble of 18 models, front view.
PDB entry 1pqr coloured by chain, ensemble of 18 models, side view.
PDB entry 1pqr coloured by chain, ensemble of 18 models, top view.
Source organism: Conus ermineus
Primary publication:
Solution conformation of alphaA-conotoxin EIVA, a potent neuromuscular nicotinic acetylcholine receptor antagonist from Conus ermineus.
Chi SW, Park KH, Suk JE, Olivera BM, McIntosh JM, Han KH
J Biol Chem 278 42208-13 (2003)
PMID: 12900418

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin EIVA Chain: A
Molecule details ›
Chain: A
Length: 31 amino acids
Theoretical weight: 3.11 KDa
Source organism: Conus ermineus
Expression system: Not provided
UniProt:
  • Canonical: P58782 (Residues: 1-30; Coverage: 100%)
Sequence domains: Alpha-A conotoxin PIVA-like protein

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 5 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, molecular dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Marine natural products.
Blunt et al. (2005)
3 more

2 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
1 more