› 1oko

X-ray diffraction
1.6Å resolution

Crystal structure of Pseudomonas Aeruginosa Lectin 1 complexed with galactose at 1.6 A resolution

Released:
DOI: 10.2210/pdb1oko/pdb
PDB entry 1oko coloured by chain, front view.
PDB entry 1oko coloured by chain, side view.
PDB entry 1oko coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Primary publication:
Structural basis of calcium and galactose recognition by the lectin PA-IL of Pseudomonas aeruginosa.
Cioci G, Mitchell EP, Gautier C, Wimmerová M, Sudakevitz D, Pérez S, Gilboa-Garber N, Imberty A
FEBS Lett 555 297-301 (2003)
PMID: 14644431

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PA-I galactophilic lectin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 121 amino acids
Theoretical weight: 12.77 KDa
Source organism: Pseudomonas aeruginosa
UniProt:
  • Canonical: Q05097 (Residues: 2-122; Coverage: 99%)
Gene names: PA2570, lecA, pa1L
Sequence domains: PA-IL-like protein
Structure domains: Galactose-binding lectin

Ligands and Environments

5 bound ligands:
Ligand CA 4 x CA
Ligand GAL 4 x GAL
Ligand SO4 3 x SO4
Ligand MPD 1 x MPD
Ligand GLA 3 x GLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 49.057Å b: 53.275Å c: 160.675Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.154 0.187

Quick links

Citations

9 review citations

Multivalent glycoconjugates as anti-pathogenic agents.
Bernardi et al. (2013)
8 more

18 mentions without citation

From carbohydrate leads to glycomimetic drugs.
Ernst et al. (2009)
17 more