1nn6

X-ray diffraction
1.75Å resolution

Human Pro-Chymase

Released:

Function and Biology Details

Reaction catalysed:
Preferential cleavage: Phe-|- > Tyr-|- > Trp-|- > Leu-|-.
Biochemical function:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chymase Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23946 (Residues: 20-247; Coverage: 100%)
Gene names: CMA1, CYH, CYM
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 50.688Å b: 55.639Å c: 88.686Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.245
Expression system: Spodoptera frugiperda