1nn5

X-ray diffraction
1.5Å resolution

Crystal structure of human thymidylate kinase with d4TMP + AppNHp

Released:

Function and Biology Details

Reaction catalysed:
ATP + dTMP = ADP + dTDP
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate kinase Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 24.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23919 (Residues: 1-212; Coverage: 100%)
Gene names: CDC8, DTYMK, TMPK, TYMK
Sequence domains: Thymidylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P43212
Unit cell:
a: 101.1Å b: 101.1Å c: 49.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.192 0.215
Expression system: Escherichia coli