X-ray diffraction
2.75Å resolution

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A


Function and Biology Details

Reaction catalysed:
A cerebroside 3-sulfate + H(2)O = a cerebroside + sulfate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Arylsulfatase A Chain: A
Molecule details ›
Chain: A
Length: 489 amino acids
Theoretical weight: 52.04 KDa
Source organism: Homo sapiens
  • Canonical: P15289 (Residues: 19-507; Coverage: 100%)
  • Best match: P15289-2 (Residues: 1-423)
Gene name: ARSA
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I422
Unit cell:
a: 131.52Å b: 131.52Å c: 192.17Å
α: 90° β: 90° γ: 90°
R R work R free
0.216 0.202 0.239