› 1mxu

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments)

Released:
DOI: 10.2210/pdb1mxu/pdb
PDB entry 1mxu coloured by chain, front view.
PDB entry 1mxu coloured by chain, side view.
PDB entry 1mxu coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Jin R, Gouaux E
Biochemistry 42 5201-13 (2003)
PMID: 12731861

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 263 amino acids
Theoretical weight: 29.22 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand ZN 5 x ZN
Ligand BWD 3 x BWD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21212
Unit cell:
a: 114.292Å b: 163.403Å c: 48.072Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
10 more