1m7e

X-ray diffraction
2.45Å resolution

Crystal structure of the phosphotyrosine binding domain(PTB) of mouse Disabled 2(Dab2):implications for Reeling signaling

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disabled homolog 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 160 amino acids
Theoretical weight: 18.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P98078 (Residues: 33-191; Coverage: 21%)
Gene names: Dab2, Doc2
Sequence domains: Phosphotyrosine interaction domain (PTB/PID)
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
C31 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P08592 (Residues: 755-763; Coverage: 1%)
Gene name: App

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR571
Spacegroup: R32
Unit cell:
a: 127.258Å b: 127.258Å c: 269.541Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.244 0.273
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided