X-ray diffraction
2Å resolution

Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Adenomatous polyposis coli protein Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P25054 (Residues: 126-250; Coverage: 4%)
Gene names: APC, DP2.5
Sequence domains: Adenomatous polyposis coli tumour suppressor protein
Structure domains: Helix hairpin bin

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3221
Unit cell:
a: 46.047Å b: 46.047Å c: 113.299Å
α: 90° β: 90° γ: 120°
R R work R free
0.262 0.257 0.309
Expression system: Escherichia coli BL21