PDBe 1ly7

Solution NMR

The solution structure of the the c-terminal domain of frataxin, the protein responsible for friedreich ataxia

Released:

Function and Biology Details

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frataxin mature form Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q16595 (Residues: 90-210; Coverage: 58%)
Gene names: FRDA, FXN, X25
Sequence domains: Frataxin-like domain
Structure domains: Frataxin/CyaY

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Chemical shifts: BMR4342  
Expression system: Escherichia coli BL21