PDBe 1lw3

X-ray diffraction
2.3Å resolution

Crystal Structure of Myotubularin-related protein 2 complexed with phosphate


Function and Biology Details

Reactions catalysed:
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate
1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol + phosphate

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Myotubularin-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 657 amino acids
Theoretical weight: 75.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q13614 (Residues: 1-643; Coverage: 100%)
  • Best match: Q13614-2 (Residues: 1-571)
Gene names: KIAA1073, MTMR2
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 5ID-B
Spacegroup: P41212
Unit cell:
a: 66.08Å b: 66.08Å c: 261.41Å
α: 90° β: 90° γ: 90°
R R work R free
0.25 0.209 0.273
Expression system: Escherichia coli BL21(DE3)