1lqs

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF HUMAN CYTOMEGALOVIRUS IL-10 BOUND TO SOLUBLE HUMAN IL-10R1

Released:
Primary publication:
Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1.
Proc. Natl. Acad. Sci. U.S.A. 99 9404-9 (2002)
PMID: 12093920

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-10 receptor subunit alpha Chains: R, S
Molecule details ›
Chains: R, S
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q13651 (Residues: 22-235; Coverage: 38%)
Gene names: IL10R, IL10RA
Structure domains: Immunoglobulins
Viral interleukin-10 homolog Chains: L, M
Molecule details ›
Chains: L, M
Length: 157 amino acids
Theoretical weight: 18.14 KDa
Source organism: Human betaherpesvirus 5
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P17150 (Residues: 20-29, 30-175; Coverage: 100%)
Gene name: UL111A
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 114.29Å b: 104.68Å c: 91.89Å
α: 90° β: 106.49° γ: 90°
R-values:
R R work R free
0.244 0.244 0.294
Expression system: Drosophila melanogaster