› 1lmm

Solution NMR

Solution Structure of Psmalmotoxin 1, the First Characterized Specific Blocker of ASIC1a NA+ channel

Released:
DOI: 10.2210/pdb1lmm/pdb
PDB entry 1lmm coloured by chain, ensemble of 20 models, front view.
PDB entry 1lmm coloured by chain, ensemble of 20 models, side view.
PDB entry 1lmm coloured by chain, ensemble of 20 models, top view.
Source organism: Psalmopoeus cambridgei
Primary publication:
Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.
Escoubas P, Bernard C, Lambeau G, Lazdunski M, Darbon H
Protein Sci 12 1332-43 (2003)
PMID: 12824480

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Psalmotoxin-1 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.71 KDa
Source organism: Psalmopoeus cambridgei
Expression system: Escherichia coli
UniProt:
  • Canonical: P60514 (Residues: 1-40; Coverage: 100%)
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli

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Citations

27 review citations

International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.
Kellenberger et al. (2015)
26 more

8 mentions without citation

Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.
Wu et al. (2019)
7 more