X-ray diffraction
2.5Å resolution

DNA recognition is mediated by conformational transition and by DNA bending


Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Entry contents:
1 distinct polypeptide molecule
Runt-related transcription factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 131 amino acids
Theoretical weight: 14.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q01196 (Residues: 51-181; Coverage: 29%)
Gene names: AML1, CBFA2, RUNX1
Sequence domains: Runt domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: R32
Unit cell:
a: 121.23Å b: 121.23Å c: 186.33Å
α: 90° β: 90° γ: 120°
R R work R free
0.195 0.193 0.249
Expression system: Escherichia coli