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X-ray diffraction
2.4Å resolution

X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotonin N-acetyltransferase Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 23.11 KDa
Source organism: Ovis aries
Expression system: Escherichia coli
UniProt:
  • Canonical: Q29495 (Residues: 1-207; Coverage: 100%)
Gene names: AANAT, SNAT
Sequence domains: Acetyltransferase (GNAT) family
Structure domains: Aminopeptidase

Ligands and Environments


Cofactor: Ligand COT 1 x COT
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2221
Unit cell:
a: 53.152Å b: 68.79Å c: 89.651Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.203 0.276
Expression system: Escherichia coli