1kup

Solution NMR

Solution Structure of the Membrane Proximal Regions of alpha-IIb and beta-3 Integrins

Released:
Source organism: Homo sapiens
Primary publication:
Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits.
Proc. Natl. Acad. Sci. U.S.A. 99 5878-83 (2002)
PMID: 11983888

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin alpha-IIb light chain, form 2 Chain: A
Molecule details ›
Chain: A
Length: 11 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P08514 (Residues: 1018-1028; Coverage: 1%)
Gene names: GP2B, ITGA2B, ITGAB
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 25 amino acids
Theoretical weight: 3.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05106 (Residues: 742-766; Coverage: 3%)
Gene names: GP3A, ITGB3

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics, matrix relaxation, torsion angle dynamics
Expression system: Not provided