PDBe 1iz2

X-ray diffraction
2.2Å resolution

Interactions causing the kinetic trap in serpin protein folding

Released:
Source organism: Homo sapiens
Primary publication:
Interactions causing the kinetic trap in serpin protein folding.
J. Biol. Chem. 277 46347-54 (2002)
PMID: 12244055

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-antitrypsin Chain: A
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 44.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01009 (Residues: 25-418; Coverage: 100%)
  • Best match: P01009-2 (Residues: 25-355)
Gene names: AAT, PI, PRO0684, PRO2209, SERPINA1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 6B
Spacegroup: P212121
Unit cell:
a: 63.02Å b: 74.173Å c: 93.115Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.211 0.278
Expression system: Escherichia coli