› 1ie4

X-ray diffraction
2.5Å resolution

RAT TRANSTHYRETIN COMPLEX WITH THYROXINE (T4)

Released:
DOI: 10.2210/pdb1ie4/pdb
PDB entry 1ie4 coloured by chain, front view.
PDB entry 1ie4 coloured by chain, side view.
PDB entry 1ie4 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites.
Wojtczak A, Cody V, Luft JR, Pangborn W
Acta Crystallogr D Biol Crystallogr 57 1061-70 (2001)
PMID: 11468389

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136174 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 13.61 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P02767 (Residues: 21-147; Coverage: 100%)
Gene names: Tt, Ttr
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand T44 2 x T44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43212
Unit cell:
a: 82.526Å b: 82.526Å c: 161.844Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.209 0.275

Quick links

Citations

8 review citations

The Halogen Bond.
Cavallo et al. (2016)
7 more

6 mentions without citation

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors.
Guo et al. (2020)
5 more