1hx1

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF A BAG DOMAIN IN COMPLEX WITH THE HSC70 ATPASE DOMAIN

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock cognate 71 kDa protein Chain: A
Molecule details ›
Chain: A
Length: 400 amino acids
Theoretical weight: 44.51 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19120 (Residues: 4-381; Coverage: 58%)
Gene names: HSC70, HSPA8
Structure domains:
BAG family molecular chaperone regulator 1 Chain: B
Molecule details ›
Chain: B
Length: 114 amino acids
Theoretical weight: 13.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99933 (Residues: 222-334; Coverage: 33%)
Gene names: BAG1, HAP
Sequence domains: BAG domain
Structure domains: BAG domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6, ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 116.57Å b: 40.78Å c: 129.26Å
α: 90° β: 114.84° γ: 90°
R-values:
R R work R free
0.234 0.234 0.279
Expression system: Escherichia coli