› 1gnc

Solution NMR

STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN

Released:
DOI: 10.2210/pdb1gnc/pdb
PDB entry 1gnc coloured by chain, ensemble of 10 models, front view.
PDB entry 1gnc coloured by chain, ensemble of 10 models, side view.
PDB entry 1gnc coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein.
Zink T, Ross A, Lüers K, Cieslar C, Rudolph R, Holak TA
Biochemistry 33 8453-63 (1994)
PMID: 7518249

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140818 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Granulocyte colony-stimulating factor Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09919 (Residues: 31-207; Coverage: 100%)
Gene names: C17orf33, CSF3, GCSF
Sequence domains: Granulocyte colony-stimulating factor
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

4 review citations

Interleukin-6: structure-function relationships.
Simpson et al. (1997)
3 more

11 mentions without citation

Biosimilar G-CSF based mobilization of peripheral blood hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
Schmitt et al. (2014)
10 more