› 1g1q

X-ray diffraction
2.4Å resolution

Crystal structure of P-selectin lectin/EGF domains

Released:
DOI: 10.2210/pdb1g1q/pdb
PDB entry 1g1q coloured by chain, front view.
PDB entry 1g1q coloured by chain, side view.
PDB entry 1g1q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
Somers WS, Tang J, Shaw GD, Camphausen RT
Cell 103 467-79 (2000)
PMID: 11081633

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147622 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P-selectin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 162 amino acids
Theoretical weight: 19.13 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P16109 (Residues: 42-199; Coverage: 20%)
Gene names: GMRP, GRMP, SELP
Sequence domains: Lectin C-type domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand MRD 2 x MRD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 81Å b: 60.83Å c: 91.44Å
α: 90° β: 103.58° γ: 90°
R-values:
R R work R free
0.213 0.213 0.252
Expression system: Cricetulus griseus

Quick links

Citations

95 review citations

Neutrophils, from marrow to microbes.
Borregaard N. (2010)
94 more

16 mentions without citation

Rolling cell adhesion.
McEver et al. (2010)
15 more