› 1ftk

X-ray diffraction
1.6Å resolution

CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION

Released:
DOI: 10.2210/pdb1ftk/pdb
PDB entry 1ftk coloured by chain, front view.
PDB entry 1ftk coloured by chain, side view.
PDB entry 1ftk coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Armstrong N, Gouaux E
Neuron 28 165-81 (2000)
PMID: 11086992

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 30.74 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 404-528, 653-796; Coverage: 31%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand KAI 1 x KAI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P21
Unit cell:
a: 43.36Å b: 63.12Å c: 46.38Å
α: 90° β: 92.79° γ: 90°
R-values:
R R work R free
0.24 0.216 0.261
Expression system: Escherichia coli

Quick links

Citations

100 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
99 more

11 mentions without citation

Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
Zhou et al. (2017)
10 more