PDBe 1fsu

X-ray diffraction
2.5Å resolution

Crystal Structure of 4-Sulfatase (human)

Source organism: Homo sapiens
Primary publication:
Structure of a human lysosomal sulfatase.
Structure 5 277-89 (1997)
PMID: 9032078

Function and Biology Details

Reaction catalysed:
Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Arylsulfatase B Chain: A
Molecule details ›
Chain: A
Length: 492 amino acids
Theoretical weight: 55.82 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P15848 (Residues: 42-533; Coverage: 99%)
Gene name: ARSB
Sequence domains: Sulfatase
Structure domains:

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P41212
Unit cell:
a: 107Å b: 107Å c: 144.83Å
α: 90° β: 90° γ: 90°
R R work R free
0.188 0.188 0.243
Expression system: Cricetulus griseus