1f68

Solution NMR

NMR SOLUTION STRUCTURE OF THE BROMODOMAIN FROM HUMAN GCN5

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase KAT2A Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92830 (Residues: 731-832; Coverage: 12%)
Gene names: GCN5, GCN5L2, KAT2A
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Torsion angle dynamics (DYANA) for generation of initial structures; Structure-mediated assignment of ambiguous experimental restraints (SANE); Iteration between DYANA and SANE; Simulated Annealing and Energy Minimization in AMBER using full restraint set.
Expression system: Escherichia coli