PDBe 1f2s

X-ray diffraction
1.79Å resolution

CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND MCTI-A, A TRYPSIN INHIBITOR OF SQUASH FAMILY AT 1.8 A RESOLUTION

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cationic trypsin Chain: E
Molecule details ›
Chain: E
Length: 223 amino acids
Theoretical weight: 23.32 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Trypsin inhibitor 2 Chain: I
Molecule details ›
Chain: I
Length: 28 amino acids
Theoretical weight: 3.25 KDa
Source organism: Momordica charantia
UniProt:
  • Canonical: P10295 (Residues: 1-28; Coverage: 100%)
Sequence domains: Squash family serine protease inhibitor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 59.76Å b: 55.55Å c: 74.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.177 0.226