PDBe 1ekg

X-ray diffraction
1.8Å resolution

MATURE HUMAN FRATAXIN

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human frataxin.
J. Biol. Chem. 275 30753-6 (2000)
PMID: 10900192

Function and Biology Details

Reaction catalysed:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Frataxin mature form Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16595 (Residues: 84-210; Coverage: 61%)
Gene names: FRDA, FXN, X25
Sequence domains: Frataxin-like domain
Structure domains: Frataxin/CyaY

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 44.05Å b: 45.22Å c: 68.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.197 0.22
Expression system: Escherichia coli