1ee4

X-ray diffraction
2.1Å resolution

CRYSTAL STRUCTURE OF YEAST KARYOPHERIN (IMPORTIN) ALPHA IN A COMPLEX WITH A C-MYC NLS PEPTIDE

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 423 amino acids
Theoretical weight: 46.87 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
  • Canonical: Q02821 (Residues: 87-509; Coverage: 78%)
Gene names: KAP60, N1606, SRP1, YNL189W
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Myc proto-oncogene protein Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 9 amino acids
Theoretical weight: 1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01106 (Residues: 320-328; Coverage: 2%)
Gene names: BHLHE39, MYC

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 42.68Å b: 85.85Å c: 117.5Å
α: 90° β: 93.42° γ: 90°
R-values:
R R work R free
0.246 0.246 0.277
Expression system: Not provided