1d0a

X-ray diffraction
2Å resolution

STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
Non-polymer only hexamer (preferred)
Non-polymer only dodecamer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TNF receptor-associated factor 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 168 amino acids
Theoretical weight: 19.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12933 (Residues: 334-501; Coverage: 34%)
Gene names: TRAF2, TRAP3
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Tumor necrosis factor receptor superfamily member 4 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 6 amino acids
Theoretical weight: 641 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P43489 (Residues: 261-266; Coverage: 2%)
Gene names: TNFRSF4, TXGP1L

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: C2
Unit cell:
a: 136.4Å b: 85.6Å c: 125.4Å
α: 90° β: 118.9° γ: 90°
R-values:
R R work R free
0.225 0.225 0.251
Expression systems:
  • Escherichia coli
  • Not provided