PDBe 1cx9

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-AMINOPHENYLTHIO)-BUTYLPHOSPHONIC ACID

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TRYPTOPHAN SYNTHASE (ALPHA CHAIN) Chain: A
Molecule details ›
Chain: A
Length: 268 amino acids
Theoretical weight: 28.7 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
Structure domains: Aldolase class I
TRYPTOPHAN SYNTHASE (BETA CHAIN) Chain: B
Molecule details ›
Chain: B
Length: 397 amino acids
Theoretical weight: 42.99 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
Structure domains: Rossmann fold

Ligands and Environments


Cofactor: Ligand PLP 1 x PLP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 182.65Å b: 59.34Å c: 67.3Å
α: 90° β: 94.5° γ: 90°
R-values:
R R work R free
0.219 0.21 0.276
Expression system: Escherichia coli