PDBe 1bhh

X-ray diffraction
1.9Å resolution

FREE P56LCK SH2 DOMAIN

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 119-226; Coverage: 21%)
Gene name: LCK
Sequence domains: SH2 domain
Structure domains: SH2 domain
Tyrosine-protein kinase Lck Chain: B
Molecule details ›
Chain: B
Length: 103 amino acids
Theoretical weight: 11.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06239 (Residues: 124-226; Coverage: 20%)
Gene name: LCK
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P43212
Unit cell:
a: 58.8Å b: 58.8Å c: 110.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.24 not available
Expression system: Escherichia coli