X-ray diffraction
2.4Å resolution

Crystal structure of Rous sarcoma virus protease in complex with inhibitor

Source organism: Rous sarcoma virus
Primary publication:
Structural basis for specificity of retroviral proteases.
Biochemistry 37 4518-26 (1998)
PMID: 9521772

Function and Biology Details

Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Protease p15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 124 amino acids
Theoretical weight: 13.65 KDa
Source organism: Rous sarcoma virus
  • Canonical: P03322 (Residues: 578-701; Coverage: 18%)
Gene name: gag
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P65
Unit cell:
a: 62.61Å b: 62.61Å c: 132.15Å
α: 90° β: 90° γ: 120°
R R work R free
0.175 0.175 0.293