› 1b0g

X-ray diffraction
2.5Å resolution

CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A2.1)/BETA 2-MICROGLOBULIN/PEPTIDE P1049 COMPLEX

Released:
DOI: 10.2210/pdb1b0g/pdb
PDB entry 1b0g coloured by chain, front view.
PDB entry 1b0g coloured by chain, side view.
PDB entry 1b0g coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
Zhao R, Loftus DJ, Appella E, Collins EJ
J Exp Med 189 359-70 (1999)
PMID: 9892618

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137827 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Endoplasmic reticulum membrane protein complex subunit 7 Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9NPA0 (Residues: 4-12; Coverage: 0%)
Gene names: C11orf3, C15orf24, EMC7, HT022, UNQ905/PRO1926

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P1
Unit cell:
a: 50.09Å b: 62.89Å c: 74.68Å
α: 81.98° β: 76.18° γ: 77.86°
R-values:
R R work R free
0.26 0.255 0.304
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

T cell antigen receptor recognition of antigen-presenting molecules.
Rossjohn et al. (2015)
5 more

8 mentions without citation

Modeling the structure of bound peptide ligands to major histocompatibility complex.
Tong et al. (2004)
7 more