› 1axc

X-ray diffraction
2.6Å resolution

HUMAN PCNA

Released:
DOI: 10.2210/pdb1axc/pdb
PDB entry 1axc coloured by chain, front view.
PDB entry 1axc coloured by chain, side view.
PDB entry 1axc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA.
Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J
Cell 87 297-306 (1996)
PMID: 8861913

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146046 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proliferating cell nuclear antigen Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 261 amino acids
Theoretical weight: 28.8 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12004 (Residues: 1-261; Coverage: 100%)
Gene name: PCNA
Sequence domains:
Structure domains: Proliferating Cell Nuclear Antigen
Cyclin-dependent kinase inhibitor 1 Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 22 amino acids
Theoretical weight: 2.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P38936 (Residues: 139-160; Coverage: 13%)
Gene names: CAP20, CDKN1, CDKN1A, CIP1, MDA6, PIC1, SDI1, WAF1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P3221
Unit cell:
a: 83.5Å b: 83.5Å c: 233.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.192 0.289

Quick links

Citations

83 review citations

PCNA, the maestro of the replication fork.
Moldovan et al. (2007)
82 more

87 mentions without citation

Human PCNA Structure, Function and Interactions.
González-Magaña et al. (2020)
86 more