› 1atd

Solution NMR

HIGH-RESOLUTION STRUCTURE OF ASCARIS TRYPSIN INHIBITOR IN SOLUTION: DIRECT EVIDENCE FOR A PH INDUCED CONFORMATIONAL TRANSITION IN THE REACTIVE SITE

Released:
DOI: 10.2210/pdb1atd/pdb
PDB entry 1atd coloured by chain, ensemble of 32 models, front view.
PDB entry 1atd coloured by chain, ensemble of 32 models, side view.
PDB entry 1atd coloured by chain, ensemble of 32 models, top view.
Source organism: Ascaris suum
Primary publication:
High-resolution structure of Ascaris trypsin inhibitor in solution: direct evidence for a pH-induced conformational transition in the reactive site.
Grasberger BL, Clore GM, Gronenborn AM
Structure 2 669-78 (1994)
PMID: 7922043

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148567 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypsin inhibitor Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 6.81 KDa
Source organism: Ascaris suum
Expression system: Not provided
UniProt:
  • Canonical: P19398 (Residues: 1-62; Coverage: 100%)
Sequence domains: Trypsin Inhibitor like cysteine rich domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

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Citations

5 review citations

Proteases in parasitic diseases.
McKerrow et al. (2006)
4 more